Design of live-attenuated animal vaccines based on pseudorabies virus platform
نویسندگان
چکیده
Abstract Pseudorabies virus (PRV) is a double-stranded DNA with genome approximating 150 kb in size. PRV contains many non-essential genes that can be replaced encoding heterogenous antigens without affecting viral propagation. With the ability to induce cellular, humoral and mucosal immune responses host, considered an ideal potential live vector for generation of animal vaccines. In this review, we summarize advances attenuated recombinant PRVs design PRV-based vaccines as well challenge vaccine application.
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ژورنال
عنوان ژورنال: Animal Diseases
سال: 2022
ISSN: ['2731-0442']
DOI: https://doi.org/10.1186/s44149-022-00044-w